Potensi Pisang Klutuk Terfortifikasi Fe dan Lactobacillus Sebagai Pangan Fungsional Penanganan Anemia

Nadia Yasmine; Enrique Aldrin; Yafi Surya Permana; Arta Farmawati

doi:10.33085/jdg.v5i2.5332

Potensi Pisang Klutuk Terfortifikasi Fe dan Lactobacillus Sebagai Pangan Fungsional Penanganan Anemia

Nadia Yasmine, Enrique Aldrin, Yafi Surya Permana, Arta Farmawati

Abstract

Latar Belakang; anemia merupakan masalah kesehatan global. Akan tetapi, suplementasi zat besi (Fe) yang merupakan terapi standar anemia dapat menimbulkan ketidakseimbangan mikrobiota usus dan gangguan gastrointestinal. Memberikan suplementasi zat besi dengan kombinasi probiotik dan prebiotik diharapkan dapat mengatasi masalah ini. Pisang klutuk diketahui memiliki kandungan gizi paling tinggi dibandingkan dengan jenis pisang lain, sehingga berpotensi sebagai prebiotik. Tujuan; untuk mengkaji efek probiotik dan prebiotik terhadap penyerapan zat besi dan status zat besi serta mengkaji potensi sinbiotik tepung pisang klutuk fortifikasi zat besi dan Lactobacillus sp. sebagai pangan fungsional untuk mengatasi anemia defisiensi zat besi. Metode; jenis penelitian studi literatur menggunakan data sekunder yang diperoleh dari artikel penelitian asli yang dipublikasikan pada tahun 2010-2020 dengan skrining kriteria inklusi dan eksklusi artikel. Data dianalisis secara deskriptif. Hasil; probiotik dan prebiotik memiliki peran penting dalam meningkatkan penyerapan zat besi. Pisang klutuk merupakan sumber prebiotik inulin dan fruktooligosakarida yang berperan secara signifikan menurunkan pH dan meningkatkan jumlah probiotik di usus. Lactobacillus sp. yang berperan sebagai probiotik terbukti dapat meningkatkan produksi metabolit bakteri, sekresi musin, dan respon anti-inflamasi, serta dapat meningkatkan kelarutan dan penyerapan zat besi oleh divalent metal transporter-1 di usus. Prebiotik pisang klutuk dan probiotik Lactobacillus sp. berpotensi dimanfaatkan sebagai produk sinbiotik yang dapat meningkatkan penyerapan zat besi. Pemberian zat besi yang dibersamai oleh produk sinbiotik ini berpotensi lebih optimal dalam menangani anemia defisiensi zat besi. Kesimpulan; sinbiotik tepung pisang klutuk terfortifikasi zat besi dan Lactobacillus sp. berpotensi dikembangkan menjadi pangan fungsional untuk mengatasi anemia.

Keywords

Anemia; Pisang Klutuk; Lactobacillus sp.; Besi; Mikrobiota

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References

Mazrizal I, IAM S. Anemia defisiensi besi. Jurnal Kesehatan Masyarakat Andalas. 2017;2(1):140-5.

Turner J, Parsi M, Badireddy M. Anemia. In: StatPearls [Internet]. Florida, USA: StatPearls Publishing. Diakses dari: https://pubmed.ncbi.nlm.nih.gov/29763170/ tanggal 4 September, 2020.

Kementerian Kesehatan RI. Riset Kesehatan Dasar. Jakarta: Balitbang Kementerian Kesehatan Republik Indonesia; 2013.

Kassebaum N, Collaborators GBDA. The global burden of anemia. Hematol Oncol Clin North Am. 2016;30(2):247-308.

Vonderheid S, Tussing-Humphreys L, Park C, Pauls H, OjiNjideka Hemphill N, LaBomascus B, et al. A systematic review and meta-analysis on the effects of probiotic species on iron absorption and iron status. Nutrients. 2019;11(12):2938.

Ozdemir N. Iron deficiency anemia from diagnosis to treatment in children. Turk Pediatri Ars. 2015;50(1):11-9.

Flores-Quijano ME, Vega-Sanchez R, Tolentino-Dolores MC, Lopez-Alarcon MG, Flores-Urrutia MC, Lopez-Olvera AD, et al. Obesity is associated with changes in iron nutrition status and its homeostatic regulation in pregnancy. Nutrients. 2019;11(3).

Beck KL, Conlon CA, Kruger R, Coad J. Dietary determinants of and possible solutions to iron deficiency for young women living in industrialized countries: A review. Nutrients. 2014;6(9):3747-76.

Tolkien Z, Stecher L, Mander AP, Pereira DI, Powell JJ. Ferrous sulfate supplementation causes significant gastrointestinal side-effects in adults: A systematic review and meta-analysis. PLoS One. 2015;10(2):e0117383.

Zimmermann MB, Zeder C, Muthayya S, Winichagoon P, Chaouki N, Aeberli I, et al. Adiposity in women and children from transition countries predicts decreased iron absorption, iron deficiency and a reduced response to iron fortification. Int J Obes (Lond). 2008;32(7):1098-104.

Paganini D, Zimmermann MB. The effects of iron fortification and supplementation on the gut microbiome and diarrhea in infants and children: A review. Am J Clin Nutr. 2017;106(Suppl 6):1688S-93S.

Torre-Gutierrez Ldl, Guerrero L, Betancur D. Functional properties of square banana (Musa balbisiana) starch. Food Chem. 2008;106(3):1138-14.

Cruz-Cardenas CI, Miranda-Ham ML, Castro-Concha LA, Ku-Cauich JR, Vergauwen R, Reijnders T, et al. Fructans and other water soluble carbohydrates in vegetative organs and fruits of different Musa spp. Accessions. Front Plant Sci. 2015;6:395.

Ahsin A, Wijayanti H, Afifah D. Aktivitas antioksidan, kadar pati resisten, dan organoleptik es krim pisang batu (Musa balbisiana Colla) sebagai makanan fungsional untuk pencegahan penyakit kanker kolorektal. Journal of Nutrition College. 2019;8(3):115-22.

Shoaib M, Shehzad A, Omar M, Rakha A, Raza H, Sharif HR, et al. Inulin: Properties, health benefits and food applications. Carbohydr Polym. 2016;147:444-54.

Gibson G, Scott K, Rastall R, Tuohy K, Hotchkiss A, Dubert-Ferrandon A, et al. Dietary prebiotics: Current status and new definition. Food Sci Technol Bull Funct Foods. 2010;7:1-19.

Hoppe M, Onning G, Hulthen L. Freeze-dried Lactobacillus plantarum 299v increases iron absorption in young females-Double isotope sequential single-blind studies in menstruating women. PLoS One. 2017;12(12):e0189141.

Menezes EW, Tadini CC, Tribess TB, Zuleta A, Binaghi J, Pak N, et al. Chemical composition and nutritional value of unripe banana Flour (Musa acuminata, var. Nanicao). Plant Foods Hum Nutr. 2011;66(3):231-7.

Patel S, Goyal A. Functional oligosaccharides: Production, properties and applications. World J Microbiol Biotechnol. 2011;27:1119-28.

Pereira G, Arruda H, Molina G, Pastore G. Extraction optimization and profile analysis of oligosaccharides in banana pulp and peel. J Food Process Preserv. 2018;42:e13408.

Sunaryo W, Nurhasanah, Rahman, Sugiarto A. Identification and characterization of talas banana, a superior local cultivar from East Kalimantan (Indonesia), based on morphological and agronomical characters. Biodiversitas Journal of Biological Diversity. 2017;8(4):1414-23.

Shalini R, Antony U. Fructan distribution in banana cultivars and effect of ripening and processing on nendran banana. J Food Sci Technol. 2015;52(12):8244-51.

Kuhn R, Mazutti M, Filho F. Kinetic and mass transfer effects for adsorption of glucose, fructose, sucrose and fructooligosaccharides into X zeolite. LWT - Food Sci Technol. 2012;48(1):127-33.

Costa Ed, Alencar N, Rullo BdS, Taralo R. Effect of green banana pulp on physicochemical and sensory properties of probiotic yoghurt. Food Sci Technol, Campinas. 2017;37(3):363-8.

Mahore J, Shirolkar S. Investigation of effect of ripening and processing on prebiotic potential of banana. J Young Pharm. 2018;10(4):409-13.

Powthong P, Jantrapanukorn B, Suntornthiticharoen P, Laohaphatanalert K. Study of Prebiotic Properties of selected banana species in Thailand. J Food Sci Technol. 2020;57(7):2490-500.

Wei T, Bao JY, Yang HH, Lin JF, Zheng QW, Ye ZW, et al. Musa basjoo regulates the gut microbiota in mice by rebalancing the abundance of probiotic and pathogen. Microb Pathog. 2019;131:205-11.

Wei G, Ye Y, Yan X, Chao X, Yang F, Wang M, et al. Effect of banana pulp dietary fibers on metabolic syndrome and gut microbiota diversity in high-fat diet mice. J Food Biochem. 2020;44(9):e13362.

Dalu K, Nurhayati N, Jayus J. In vitro modulation of fecal microflora growth using fermented “pisang mas” banana and red guava juices. Curr Res Nutr Food Sci. 2019;7(2):449-56.

Shalini R, Abinaya G, Saranya P, Antony U. Growth of selected probiotic bacterial strains with fructans from nendran banana and garlic. LWT - Food Sci Technol. 2017;83:68-78.

Freitas Kde C, Amancio OM, de Morais MB. High-performance inulin and oligofructose prebiotics increase the intestinal absorption of iron in rats with iron deficiency anaemia during the growth phase. Br J Nutr. 2012;108(6):1008-16.

Marciano R, Santamarina AB, de Santana AA, Silva Mde L, Amancio OM, do Nascimento CM, et al. Effects of prebiotic supplementation on the expressionof proteins regulating iron absorption in anaemic growing rats. Br J Nutr. 2015;113(6):901-8.

Skrypnik K, Bogdanski P, Schmidt M, Suliburska J. The effect of multispecies probiotic supplementation on iron status in rats. Biol Trace Elem Res. 2019;192(2):234-43.

Hoppe M, Onning G, Berggren A, Hulthen L. Probiotic strain Lactobacillus plantarum 299v increases iron absorption from 2 an iron-supplemented fruit drink: A double-isotope cross-over single-blind 3 study in women of reproductive age--ERRATUM. Br J Nutr. 2015;114(11):1948.

Manoppo J, Tasiringan H, Wahani A, Umboh A, Mantik M. The role of Lactobacillus reuteri DSM 17938 for the absorption of iron preparations in children with iron deficiency anemia. Korean J Pediatr. 2019;62(5):173-8.

Gonzalez A, Galvez N, Martin J, Reyes F, Perez-Victoria I, Dominguez-Vera JM. Identification of the key excreted molecule by Lactobacillus fermentum related to host iron absorption. Food Chem. 2017;228:374-80.

Yilmaz B, Li H. Gut Microbiota and iron: The crucial actors in health and disease. Pharmaceuticals (Basel). 2018;11(4).

Suzuki Y, Kosaka M, Shindo K, Kawasumi T, Kimoto-Nira H, Suzuki C. Identification of antioxidants produced by Lactobacillus plantarum. Biosci Biotechnol Biochem. 2013;77(6):1299-302.

Vogado CO, Leandro EDS, Zandonadi RP, de Alencar ER, Ginani VC, Nakano EY, et al. Enrichment of probiotic fermented milk with green banana pulp: Characterization microbiological, physicochemical and sensory. Nutrients. 2018;10(4).

Desnilasari D, Lestari N. formulasi minuman sinbiotik dengan penambahan puree pisang ambon (Musa paradisiaca var sapientum) dan inulin menggunakan inokulum Lactobacillus casei. J Agritech. 2014;34(3).

DOI: https://doi.org/10.33085/jdg.v5i2.5332