.png){kind=small}
Pengaruh Daun Pepaya (Carica papaya L.) terhadap Peningkatan Trombosit pada Pasien Demam Berdarah Dengue
Abstract
Demam berdarah dengue merupakan penyakit infeksi yang disebabkan oleh virus dengue dan dibawa oleh nyamuk Aedes aegypti. Penyakit ini menyebabkan peningkatan hematokrit, penurunan hemoglobin, leukosit normal atau menurun, dan penurunan trombosit (trombositopenia). Trombositopenia merupakan salah satu faktor risiko terjadinya perdarahan. Salah satu tanaman yang mampu meningkatkan trombosit pada pasien demam berdarah adalah daun pepaya. Kandungan enzim proteinolitik seperti papain dan chymopapain dapat membantu meningkatkan jumlah trombosit, fraksi alkaloid (carpaine) terbukti bertanggung jawab atas aktivitas anti-trombositopenia, serta flavonol dan flavonoid menstimulan produksi sel darah, menghambat NS2B-NS3 protease dan mencegah perakitan virus DEN-2. Daun pepaya juga mempengaruhi produksi Gen ALOX-12 dan PTAFR yang berperan dalam produksi trombosit. Pada review ini, pencarian data primer dilakukan dengan secara online, berupa jurnal nasional maupun jurnal internasional 10 tahun terakhir (2009-2017). Hasil diperoleh dari beberapa jurnal dan sumber lainnya dapat diketahui mekanisme pengaruh daun pepaya dalam meningkatkan trombosit.
Keywords
Full Text:
PDFReferences
Askandar T, dkk. Buku Ajar Ilmu Penyakit Dalam. Edisi Ke-1. Surabaya: FK UNAIR; 2015. p. 125.
World Health Organization. Dengue and Severe Dengue. Raised and. Geneva; 2019.
Kementerian Kesehatan RI. Pusat Data dan Informasi. Jakarta: Kementerian Kesehatan Republik Indonesia; 2016.
Sudoyo AW, Setiyohadi B, Alwi I. Buku Ajar Ilmu Penyakit Dalam. Edisi Kelima. Jilid III. Jakarta: Internal Publishing Pusat Penerbitan Ilmu Penyakit Dalam; 2009. p. 177.
Yogiraj V, Goyal PK, Chauhan CS. Carica papaya Linn : An Overview. 2015;2(5):1–8.
World Health Organization. Comprehensive Guidelines for Prevention and Control of Dengue and Dengue Haemorrhagic Fever. World Health Organization. 2011;
Hadi UK, Soviana S, Sugiarto. Transovarial Transmission of Dengue Virus on Aedes aegypti at Several Endemic Areas of Dengue Haemorrhagic Fever in Indonesia IOP Publ. 2018;1–8.
Balsitis SJ, Coloma J, Castro G Alava A, Flores D, Mckerrow JH, et al. Tropism of Dengue Virus in Mice and Humans Defined by Viral Nonstructural Protein 3-Specific Immunostaining. 2009;80(3):416–24.
Durbin AP, Vargas MJ, Wanionek K, Hammond SN, Gordon A, Rocha C, et al. Phenotyping of Peripheral Blood Mononuclear Cells During Acute Dengue Illness Demonstrates Infection and Increased Activation of Monocytes in Severe Cases Compared to Classic Dengue Fever. Virology. 2008;376(2):429–35.
Guzman MG, Halstead SB, Artsob H, Buchy P, Farrar J, Nathan MB, et al. Dengue : A Continuing Global Threat. 2015;8(12 0):1–26.
Ikatan Dokter Anak Indonesia. Buku Ajar Infeksi dan Pediatri Tropis. Edisi ke-2. Jakarta: Badan Penerbit IDAI; 2012. p. 17.
Chen K, Pohan HT, Sinto R. Diagnosis dan Terapi Cairan pada Demam Berdarah Dengue. J Med. 2009;22(1):3–7.
Puspitasari Y, Peristiowati Y. Effect of Papaya Leaf Extract on Cell Proliferation and Apoptosis Activities in Cervical Cancer Mice Model. 2016;6(9):78–83.
Sundarmurthy D, Jayanthi CR, Lakshmaiah KC. Effect of Carica papaya Leaf Extract on Platelet Count in Chemotherapy-Induced Thrombocytopenic Patients : A preliminary study. 2017;7(7):1–8.
Sathasivam K, Ramanathan S, Mansor SM, Haris MRMH. Thrombocyte Counts in Mice After The Administration of Papaya Leaf Suspension. 2009;.
Halim SZ, Afzan A, Amini B, Rashid A, Jantan I. Acute Toxicity Study of Carica papaya Leaf Extract in Sprague Dawley Rats. 2011;
Emilio S, Melissa D, Jose A. Clinical Response in Patients with Dengue Fever to Oral Calcium Plus Vitamin D Administration : Study of 5 Cases Clinical Response in Patients With Dengue Fever to Oral Calcium Plus Vitamin D Administration : Study of 5 Cases. Proc West Pharmacol Soc. 2009;52:14–7.
Aziz J, Lide N, Kassim A, Hayaty N, Kasim A, Haque N, et al. Carica papaya Induces in Vitro Thrombopoietic Cytokines Secretion by Mesenchymal Stem Cells and Haematopoietic Cells. BMC Complement Altern Med. 2015;1–8.
Mir A, Ismatullah H, Rauf S, Niazi UHK. Identification of Bioflavonoid as Fusion Inhibitor of Dengue Virus Using Molecular Docking Approach Informatics in Medicine Unlocked Identification of Bioflavonoid as Fusion Inhibitor of Dengue Virus Using Molecular Docking Approach. Informatics Med Unlocked. 2016;3(June):1–6.
Senthilvel P, Lavanya P, Kumar KM, Swetha R, Anitha P, Bag S, et al. Flavonoid from Carica papaya Inhibits NS2B-NS3 Protease and Prevents Dengue 2 Viral Assembly. 2013;9(18).
Subenthiran S, Choon TC, Cheong KC, Thayan R, Teck MB, Muniandy PK, et al. Carica papaya Leaves Juice Significantly Accelerates the Rate of Increase in Platelet Count among Patients with Dengue Fever and Dengue Haemorrhagic Fever. 2013;2013.
Rahman MT, Haque N, Abdulrazaq NB, Aziz J. Current Knowledge of Dengue Pathogenesis and Potential Role of Carica papaya and Vitamins in Dengue Fever Current Knowledge of Dengue Pathogenesis and Potential Role of Carica papaya and Vitamins in Dengue Fever. 2016;33(3):512–8.
Ahmad N, Fazal H, Ayaz M, Abbasi BH, Mohammad I, Fazal L. Dengue Fever Treatment with Carica papaya Leaves Extracts. 2011;1(4):330–3.
Tjitraresmi A, Runadi D, Halimah E, Wicaksono AD. Potensi Kombinasi Herba Meniran (Phyllanthus niruri L), Daun Pepaya (Carica papaya L.) dan Rimpang Kunyit (Curcuma longa L.) sebagai Obat Herbal untuk Demam Berdarah. Farmaka. 2016;14(2):1–17.
Darmarathna SLCA, Wickramasinghe S, Waduge R, Rajapakse R, Kularatne S. Does Carica papaya Leaf-Extract Increase The Platelet Count ? An Experimental Study in A Murine Model. 2013;3(9):72.
Zunjar V, Dash RP, Jivrajani M, Nivsarkar M. Antithrombocytopenic Activity of Carpaine and Alkaloidal Extract of Carica papaya Linn. Leaves in Busulfan Induced Thrombocytopenic Wistar Rats. J Ethnopharmacol. 2016;181:20–5.
Yunita F, Hanani E, Kristianto J. The Effect of Carica papaya L . Leaves Extract Capsules on Platelets Count and Hematocrit Level in Dengue Fever Patient. 2012;2(4):573–8.
DOI: https://doi.org/10.33085/jdf.v4i1.4573
Refbacks
- There are currently no refbacks.
Sponsored/Supported by:
Contact Person:
Jl. Kapt Sumarsono 107, Helvetia, Medan, Sumatera Utara-20124, Indonesia
Hp: +6281262445695. Tel: (061) 42084606